Toxicokinetics of Polybrominated Diphenyl Ether Congeners 47, 99, 100, and 153 in Mice
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چکیده
منابع مشابه
Toxicokinetics of polybrominated diphenyl ether congeners 47, 99, 100, and 153 in mice.
The congener profiles of polybrominated diphenyl ethers (PBDEs) in human and wildlife samples are dominated by brominated diphenyl ether (BDE) congeners 47, 99, 100, 153, and 154, all of which are components of the commercial pentaBDE mixtures commonly used in a variety of flammable consumer products. Very little information is available on the toxicokinetics of these congeners and no studies a...
متن کاملPolybrominated diphenyl ether congener, BDE-47, impairs insulin sensitivity in mice with liver-specific Pten deficiency
BACKGROUND The potential health effects of polybrominated diphenyl ethers (PBDEs) that are widely used as flame-retardants in consumer products have been attributed, in part, to their endocrine disrupting properties. The purpose of this study is to examine the in vivo effects of an early exposure to PBDEs on the development of insulin resistance in mice. RESULTS The metabolic consequences of ...
متن کاملPatterns of bioaccumulation of polybrominated diphenyl ether and polychlorinated biphenyl congeners in marine mussels.
Marine mussels (Modiolus modiolus) and sediment from 14 stations near a municipal outfall and three reference locations were analyzed for polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) to evaluate and compare patterns of bioaccumulation of individual congeners between these two groups of chemicals. Of the 47 PBDEs and 209 PCBs analyzed, 34 PBDE and 153 PCB congeners...
متن کاملPolybrominated diphenyl ether congeners and toxaphene in selected marine standard reference materials.
Polybrominated diphenyl ether (PBDE) congeners and components of the complex mixture toxaphene are stable in the environment and readily bioaccumulated into wildlife and human tissues. PBDEs are presently used in large quantities worldwide as flame retardants in textiles, furniture, computer equipment, and cables. Toxaphene is a complex mixture of chlorinated bornanes and bornenes that was the ...
متن کاملIdentification of the metabolites of polybrominated diphenyl ether 99 and its related cytochrome P450s☆
OBJECTIVE To investigate the metabolites of polybrominated diphenyl ether 99 (BDE-99) and its related cytochrome P450s in an in vitro system. METHODS Rat primary hepatocytes were isolated and treated with BDE-99 for 24-72 h. Metabolites were then extracted from the hepatocytes and media, and detected by GC/MS. Several mRNAs of metabolic enzymes were also extracted from the same cells and the ...
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ژورنال
عنوان ژورنال: Toxicological Sciences
سال: 2006
ISSN: 1096-6080,1096-0929
DOI: 10.1093/toxsci/kfl091